Today, two studies that may show ways to improve quality of life for those with cardiovascular problems. Research suggests that some blood pressure drugs may protect against dementia, and injection of a growth factor may improve the repair of a heart after a heart attack.

Many people are taking blood pressure drugs for lowering blood pressure. Now there is a evidence that some members of the class of drugs known as ACE inhibitors may help protect against dementia.

The type of ACE inhibitors that seem to be effective are those that enter the brain. The brain is protected by a barrier called the blood-brain barrier, which stops many things entering the brain. This is a mechanism to protect the brain. The ACE inhibitors that can get into the brain are called “centrally-acing”.
Centrally-acting ACE inhibitors include captropril (Capoten®), fosinopril (Monopril®), lisinopril (Prinivil® or Zestri®), perindopril (Aceon®), ramipril (Altace®) and trandolapril (Mavik®). The other ACE inhibitors are not centrally acting.

The study found that those taking centrally-acting ACE inhibitors had less mental decline and dementia, than those taking other blood pressure medications. The other medications studied, including non centrally-acting ACE inhibitors had no effect on the rate of mental decline or dementia. Patients were taking other blood pressure medications were no different from those not taking blood pressure medication.

This study seems to suggest that if you have to take blood pressure medicine you might as well slow your potential mental decline and risk of dementia as the same time. Before we all rush out to change our blood pressure medicine; this is only one study and different blood pressure drugs have different effectiveness in different people.

When a heart attack occurs there is damage to the heart. The heart seems to have only a limited capacity to repair itself. This is one of the promises of stem cells. The idea is that you would bank your own stem cells at birth, and then they could be used later in life for problems such as a heart attack. (In the media stem cells seems to equal embryonic stem cells. In reality, most research is done on stem cells that did not come from embryos.)

Now researchers have shown that injecting a growth factor called neuregulin 1 may help with repairing the heart. Neuregulin 1 is a growth factor that is important for the growth and development of the heart in the fetus. In the experiments mice that had had heart attacks showed more repair if they had been injected daily with neuregulin 1, than those that had no received the growth factor. The neuregulin 1 treated mice regained much better heart function than the other mice.

Getting more heart function back after a heart attack would make a huge difference in quality of life for a large number of people. It would save money too. Lets hope that a treatment like neuregulin 1 is found to be safe and effective and become widely available soon.

photo credit: ♪ Sleeping Sun ♪

[tags]ACE inhibitors, centrally-acting ACE inhibitors, blood-brain barrier, mental decline, dementia, heart attack, neuregulin 1, growth factor, heart function[/tags]